Gulani Peptides

Pezani BPC 157 10Vials [5mg / 1Vial] - Peptides
Bokosi la 10Vials, 5mg / vial. Zonse 50mg BPC 157

Pentadecapeptide BPC 157, yopangidwa ndi 15 amino acid, ndi gawo lachitetezo cha thupi (BPC) lomwe limapezedwa ndikudzipatula kumadzi am'mimba amunthu. Mwakuyesa zawonetsedwa kuti zimathandizira kuchira kwa mabala osiyanasiyana, kuphatikiza makoswe amtundu wa Achilles tendon. Kafukufukuyu adapangidwa kuti afufuze momwe angagwiritsire ntchito BPC 157 kuti apititse patsogolo machiritso a tendon yovulala. Kukula kwa tendon fibroblasts kuchokera ku tendon explants otukuka kapena opanda BPC 157 adawunikidwa. Zotsatira zinawonetsa kuti BPC 157 imathandizira kwambiri kutuluka kwa tendon explants. Kuchulukitsa kwa ma cell amtundu wamtundu wa tendon fibroblasts wotengedwa ku makoswe Achilles tendon sikunakhudzidwe mwachindunji ndi BPC 157 monga momwe idawunikiridwa ndi mayeso a MTT.

Komabe, kupulumuka kwa maselo opangidwa ndi BPC 157 kunawonjezeka kwambiri pansi pa kupsinjika kwa H2O2. BPC 157 idakulitsa modabwitsa kusamuka kwa in vitro kwa tendon fibroblasts motengera mlingo monga momwe zimawululira ndi transwell filter migration assay. BPC 157 idathandiziranso kufalikira kwa tendon fibroblasts pazakudya zachikhalidwe modalira mlingo. Mapangidwe a F-actin monga momwe adadziwidwira ndi FITC-phalloidin staining adayambitsidwa mu BPC 157-treated fibroblasts. Maonekedwe a mapuloteni ndi kuyambitsa kwa FAK ndi paxillin kudatsimikiziridwa ndi kusanthula kwa kumadzulo kwa blot, ndipo milingo ya phosphorylation ya FAK ndi paxillin idakwera modalira mlingo ndi BPC 157 pomwe kuchuluka kwa mapuloteni sikunasinthidwe.

Pomaliza, BPC 157 imalimbikitsa ex vivo outgrowth of tendon fibroblasts kuchokera ku tendon explants, kupulumuka kwa selo pansi pa nkhawa, komanso kusuntha kwa in vitro kwa tendon fibroblasts, zomwe mwina zimalumikizidwa ndi kuyambitsa kwa FAK-paxillin njira.

Zindikirani: Sakanizani ndi Madzi a Bacteriostatic (osaphatikizidwe)