Thenga ama-Peptides

Thola i-BPC 157 10Vials [5mg / 1Vial] - Peptides
Ibhokisi le-10Vials, 5mg / vial. Isamba esingu-50mg BPC 157

I-Pentadecapeptide BPC 157, eyakhiwe ngama-amino acid ayi-15, iwukulandelana kwengxenye yenhlanganisela yokuvikela umzimba (BPC) etholwa ngaphakathi futhi yahlukaniswa nejusi yesisu somuntu. Ngokuhlolwa kuye kwaboniswa ukusheshisa ukuphulukiswa kwamanxeba amaningi ahlukene, okuhlanganisa i-rat transected Achilles tendon. Lolu cwaningo lwenzelwe ukuphenya indlela engaba khona ye-BPC 157 yokuthuthukisa ukuphulukiswa kwethenda elimele. Ukukhula kwe-tendon fibroblasts kusuka ku-tendon explants ekhuliswe nge-BPC 157 noma ngaphandle kwayo kwahlolwa. Imiphumela ibonise ukuthi i-BPC 157 isheshise kakhulu ukuphuma kwe-tendon explants. Ukusabalala kwamaseli we-cultured tendon fibroblasts atholakala ku-rat Achilles tendon akuzange kuthintwe ngokuqondile yi-BPC 157 njengoba kuhlolwe ukuhlolwa kwe-MTT.

Kodwa-ke, ukusinda kwamaseli aphethwe yi-BPC 157 kwanda kakhulu ngaphansi kwengcindezi ye-H2O2. I-BPC 157 ikhulise ngokuphawulekayo ukufuduka kwe-in vitro ye-tendon fibroblasts ngendlela encike kumthamo njengoba kwembulwe ukuhlolwa kokufuduka kwesihlungi se-transwell. I-BPC 157 iphinde yasheshisa ngokuncika komthamo ukusakazeka kwe-tendon fibroblasts ezitsheni zamasiko. Ukwakheka kwe-F-actin njengoba kutholwe yi-FITC-phalloidin staining kwafakwa kuma-fibroblasts alashwe nge-BPC 157. Isisho sephrotheni nokusebenza kwe-FAK ne-paxillin kwanqunywa ukuhlaziywa kwe-blot yaseNtshonalanga, kanye namazinga e-phosphorylation yakho kokubili i-FAK ne-paxillin akhushulwe ngokuncika kumthamo nge-BPC 157 ngenkathi inani eliphelele leprotheyini lingashintshiwe.

Sengiphetha, i-BPC 157 ikhuthaza ukuphuma kwe-ex vivo kwe-tendon fibroblasts kusuka ekufakweni kwe-tendon, ukusinda kweseli ngaphansi kwengcindezi, kanye nokufuduka kwe-in vitro kwe-tendon fibroblasts, okungenzeka ukuthi ixhunywe ngokusebenza kwendlela ye-FAK-paxillin.

Qaphela : Hlanganisa namanzi e-Bacteriostatic (akufakiwe)