I-Dolophine (i-Methadone) 10 Mg

Thenga iDolophine Online

Emhlabeni wonke, i-methadone iseyisidakamizwa esisetshenziswa kabanzi njengesinamandla i-painkiller. Ukusebenza kwe-methadone ekwelapheni ukuncika kwe-heroin kwaqala ukuboniswa ngokwesayensi ngo-1965. I-Methadone umuthi ovame kakhulu eYurophu wokwelapha esikhundleni se-opioid.

E-Finland, u-40% weziguli ezelashwa esikhundleni se-opioid zithola i-methadone, okuyiziguli ezingaphezu kuka-700. E-Finland, abantu abasebenzisa kabi ama-opioid balinganiselwa ukuthi baphakathi kwabantu abayizinkulungwane ezingu-4-6, futhi ngokuvamile basebenzisa izidakamizwa ezahlukene. Mayelana nabantu abasebenzisa kabi i-methadone, azikho izibalo eziqondile.

I-Methadone Dolophine isebenza ikakhulukazi nge-μ-opioid receptor yesistimu yezinzwa ephakathi. I-Methadone iyakwazi futhi ukuvimbela ukuthuthwa kwakho kokubili i-serotonin ne-norepinephrine kuseli. Ukuvimbela ukuthuthwa kweseli kwandisa ukusebenza kwesenzo se-analgesic.

I-Methadone Dolophine, lapho ithathwa ngomlomo, imunca ngokushesha futhi kahle, nakuba ukuchezuka okuphawulekayo komuntu ngamunye kwenzeka. Umphumela we-methadone uqala phakathi kwemizuzu engama-30-60. Umphumela wethamo elilodwa elisetshenziselwa ukudambisa izinhlungu uhlala cishe amahora angu-4, kodwa kungase kube khona ukuphambuka okuphawulekayo komuntu ngamunye. Ngokusetshenziswa okuqhubekayo, i-ejenti ihlala isikhathi eside ngenxa yokuqoqwa kwayo ezicutshini; isibonelo, ngokwelashwa kwe-opioid esikhundleni, i-methadone inikezwa kanye kuphela ngosuku. Isigamu sempilo cishe amahora angama-24. Ukunambitheka komuthi kuyababa.

Amathonya Namathonya Ayingozi Thenga I-Dolophine Online

Kubantu abangajwayele ukusebenzisa ama-opioid, i-methadone yenza okufanayo ne-morphine. I-Methadone icindezela ukusebenza kwesimiso sezinzwa esimaphakathi, ibangele ukwazi ukufiphala kanye nomuzwa wenjabulo, imilutha yezidakamizwa ewufunayo. Isicanucanu, ukuhlanza kanye nokuvinjwa kwamathumbu kuyimiphumela eyingozi evamile, njengokuntula ukudla, umlomo owomile, ukujuluka, nokukhathala.

Futhi, kungase kube nokuphulwa kwemisebenzi yocansi, ukwehlisa umfutho wegazi, ukunciphisa ukushaya kwenhliziyo kanye namajaqamba emisipha. Ngaphezu kokuqaphela amafu, i-methadone ingabangela ukucindezeleka kokuphefumula, okubhekwa njengenye yemiphumela eyingozi kakhulu. Ngenxa yomphumela ohlelweni lwe-serotonin, ukusetshenziswa kwe-methadone kwandisa ingozi yalokho okubizwa ngokuthi. i-serotonin syndrome.

Ngokusetshenziswa isikhathi eside, umzimba uyajwayela methadone Dolophine, ngakho umthengi kufanele athathe imithamo ekhuphuka njalo ukuze afinyelele umphumela awufisayo. Umzimba futhi ujwayela amathonya amaningi ayingozi, ngaphandle kwamanye (ukuvinjwa kwamathumbu kanye ne-miosis, ukuncipha komtwana weso). Ngokusetshenziswa isikhathi eside, i-methadone ayisabangeli umuzwa wenjabulo, kodwa, cishe, ivimbela ukuvela kwe-abstinence syndrome.

I-Abstinence Syndrome Thenga iDolophine Online

Ukuyeka ngokushesha ukusetshenziswa isikhathi eside kwe-methadone ngokuvamile kubangela izimpawu zokuhoxa (Ithebula 1). Ngenxa yesigamu sempilo ende ye-methadone, ukuhoxiswa kwesifo akuzwakali kangako kunokusebenzisa ama-opioid asebenza isikhathi esifushane kodwa ahlala isikhathi eside. Izimpawu zivela ngokubambezeleka futhi ziba zimbi kakhulu ezinsukwini ezingama-4-6 ngemuva kokuyeka ukungeniswa. Imvamisa, izimpawu zihlala izinsuku eziyi-10-12 kepha zingahlala isikhathi eside. Izimpawu azivamile ukusongela ukuphila.

Izimpawu

Ukuzamula, ubuthakathaka, ukucindezeleka, indle exekethile, isicanucanu

Ukujuluka, ukuconsa, ukukhala, umkhuhlane omubi, ukuthimula

Ubuhlungu emisipha, ubuhlungu ezithweni zangaphakathi, ukudlikizela emathunjini, ukuhlanza

Ukukhathazeka, ukuphazamiseka kokulala, ukucindezeleka, ukuthuthumela, ukuziphatha okuvamile ekusesheni izidakamizwa

Ukungabikho, isifiso sokudla, ukwehla kwesisindo, ukunwebeka komfundi, ukushaya kwenhliziyo njalo, amaqhuqhuva Thenga iDolophine Online

Ukwenyuka kwezinga lokushisa lomzimba, umfutho wegazi nezinga lokuphefumula, umuzwa wokugodola Thenga iDolophine Online

Ukuhlukunyezwa Nengozi Yokudlula Idosi Thenga iDolophine Online

Ngokusetshenziswa isikhathi eside, impahla ye-methadone Dolophine ibangela umuzwa wenjabulo ukuba ube buthakathaka, kodwa ngokusetshenziswa komthambo, le mpahla igcinwa ngezinga elithile. Ngesikhathi sokwamukela nge-intravenous futhi umthamo omncane owanele. Ngenxa yalezi zizathu, i-methadone isetshenziswa njengesidakamizwa emthanjeni. Ukusebenzisa ngemithambo kwenza ukuncika kube lula. I-Methadone, iyi-opioid enamandla yesenzo sesikhathi eside, ibhekwa njengeyingozi ikakhulukazi ekusetshenzisweni komthambo, kodwa futhi iyingozi kakhulu uma ithathwa ngomlomo.

Imithamo esetshenziswa ekwelapheni esikhundleni se-opioid iyabulala kubantu abasebenzisa i-opioid ngephutha futhi iyingozi kubathengi abanolwazi, ikakhulukazi uma kukhona amakhefu asetshenziswayo. Kubantu abangajwayele ama-opioid, umthamo obulalayo ungama-50-100 mg. Lapho bemukelwa ngomjovo, lo mthamo uncane. Ngokwelashwa esikhundleni se-methadone, imithamo yansuku zonke ekuqaleni kwesifundo sokuphathwa ngomlomo yi-10-40 mg, futhi ngesikhathi sokwelashwa kwesondlo ngu-60-120 mg. Uma izikhathi ezimbalwa ziphuthelwa ngesikhathi sokwelashwa, imithamo elandelayo kufanele yehliswe ngo-25-50% ukuze kulungiselelwe ukwehla kokungabekezeleleki. Ekupheleni kwenkambo yokwelapha esikhundleni, imithamo iyancipha kancane kancane, ngokwesibonelo, i-2.5-5 mg ngesonto.

Njengoba ukulungiswa kwe-methadone (amaphilisi, isisombululo) akuhloselwe ukusetshenziswa kwe-intravenous, ngenxa yokusebenzisa indlela ye-intravenous, izinto ezisizayo zingena emzimbeni, ezingavala imithambo yegazi futhi zibangele izifo ezihlukahlukene. Ukulimala kwamehlo nakho kungenzeka. Kuneminye imithi elapha ubuhlungu, Njenge-Morphine ne-OxyContin.

Ukweqisa ngokweqile ingelashwa nge-naloxone ngokufakwa emthanjeni noma ngomjovo we-intramuscular. Njengoba i-methadone inomphumela wesikhathi eside, i-naloxone ingase idinge ukunikezwa ngokuphindaphindiwe kuze kuphele isenzo se-methadone. Ngawo-2000, ukufa okubangelwa i-methadone eFinland kwanda ngokuphindwe kaningi. Ngokuvamile, kuboniswa umlando wokusetshenziswa okuxubile kwama-surfactants, ikakhulukazi i-benzodiazepines notshwala noma amanye ama-opioid.